Ozempic vs. Phentermine

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Losing weight can be a very long and difficult process. While a healthy diet and regular exercise can help in achieving your ideal weight, for many, it’s not enough, and no matter how strict they are about what they eat or how many hours they spend at the gym, the weight just doesn’t seem to want to go away.

Thankfully, however, those are not the only things you can do when trying to lose weight. When all fails, or if you simply want to have something that would make the weight loss journey more effective, you can take advantage of weight loss medications. Two popular weight loss drugs include Ozempic and Phentermine – and in this article, we’ll take a look at how they compare to each other.

Ozempic vs. Phentermine – What Are They?

Let’s start from the basics – what even are those two drugs?

What Is Ozempic

Ozempic is a medication that is actually approved by the FDA for patients with type 2 diabetes. Its main active ingredient – semaglutide – helps regulate blood sugar levels by stimulating the production of insulin when the glucose levels in the bloodstream reach a certain level by imitating a naturally occurring hormone GLP-1. It’s also effective in lowering the risk of those with both type 2 diabetes and diagnosed heart disease experiencing heart stroke, heart attack and more.

However, it also has a secondary function – it acts as an appetite suppressant due to the fact that it slows down digestion and holds the food in the stomach for longer, which results in a prolonged feeling of fullness. 

It’s for this reason that, while Ozempic is meant for diabetics, many health professionals also prescribe it to those who are overweight or obese and want to increase the effectiveness of their weight loss efforts.

How Do You Take Ozempic

Ozempic comes in the form of an injection, which should be taken weekly. It has a subcutaneous method of administration, which means that it should be given to the fatty tissues located just below the skin, in the arm, stomach, or thigh.

There are several different doses available, but you’d typically start from the smallest one – 0.25mg – and gradually increase to the strongest one, which is 2mg. Keep in mind that your healthcare professional might decide not to increase the dose to the maximum amount after taking into account your individual situation.

What Happens If I Miss a Dose

Anyone can forget to take their medication, and thankfully, in the case of Ozempic, it’s not a big deal if you don’t take it according to schedule once – however, it might become an issue if you make a habit out of it.

If you do forget to take it, take it as soon as you can (unless it’s been more than 5 days from your original administration date, in which case you should omit the forgotten dose altogether) and just take the next one according to your regular schedule.

Side Effects of Taking Ozempic

Just like any other medication, Ozempic also has some side effects that you should be aware of. Those include:


  • nausea and diarrhea
  • abdominal pain
  • constipation and bloating
  • vomiting
  • swelling/itching/redness in the place where you injected the medication
  • anxiety
  • cold sweats
  • unusual tiredness or weakness
  • low blood sugar levels


Make sure to talk to your doctor if any of the symptoms occur or if you notice a change for the worse in how you’re feeling after taking Ozempic.

What Is Phentermine

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Phentermine, on the other hand, has been approved by the Food and Drug Administration specifically as a weight loss drug. It is usually prescribed to individuals with a body mass index (BMI) greater than 30, who have tried to lose body weight in a more traditional way (via healthy diet and exercise) but haven’t managed to do so, or the results weren’t as satisfactory. A health professional might also prescribe it if your BMI is 27 or greater and you suffer from at least one weight-related condition.

This medication acts like a booster in their efforts to reduce body weight, since patients who take it are usually required to lead a healthier lifestyle by changing their diet and exercising more regularly.

Phentermine works by stimulating the central nervous system, which results in increased blood pressure and heart rate, as well as suppressed appetite, although it’s still not clear how the drug reduces appetite.

How Do You Take Phentermine

Contrary to Ozempic, which is an injection, phentermine is taken by mouth, in the form of either sustained-release capsules or tablets that dissolve in your mouth.

Phentermine is typically meant for short-term use, no longer than 12 weeks. However, a health professional might decide that it is safe to use it for longer – although this will be based on your individual situation.

They might also prescribe it for intermittent use, which means that you take it for a set period of time, then take a break from it, and then resume it again. Since your body can get used to phentermine after some time, making it less effective, allowing a break between uses can help your body wean from it.

What Happens If I Miss a Dose

If you miss a dose of phentermine, you should take it as soon as possible unless it’s almost time for your next one – in that case, don’t take the forgotten dose and just take the next one according to your regular schedule.

Missing one dose shouldn’t have any serious effects, but if you make not taking the weight loss medication a habit, it might result in it being less effective, or worse, it might stop working completely.

Side Effects of Taking Phentermine

Common side effects of using this medication include:

  • dry mouth
  • dizziness
  • headaches
  • insomnia
  • constipation
  • nausea, vomiting, diarrhea

Some of the more serious side effects include irregular heartbeat, mood changes, and uncontrolled muscle movements, while severe headache, trouble speaking, and weakness in one side of the body, among other things, are considered to be the very serious side effects, in which you should stop taking the medicine immediately.

If any of these side effects appear after you take phentermine, or if you feel worse than you felt before taking the medication, be sure to get in touch with a healthcare professional, preferably your doctor. They will determine whether your symptoms are severe enough to stop medication or if it is safe to continue with it.

How Much Weight Can You Lose on Semaglutide and Phentermine?

To answer this question, we need to take a look at some clinical trials. Let’s start with Ozempic or, more accurately, semaglutide.

One study consisted of almost two thousand adults with a body mass index of 30 (or 27 if they had at least one weight-related condition) who did not have diabetes. They were divided into two groups, one of which received placebo, while the other was administered 2.4 mg of semaglutide once a week. By week 68, the results showed that those who received a placebo noticed a weight loss of about 2.4%, while those who used semaglutide achieved impressive results of as much as 15% change in body weight compared to when they started.

As for phentermine, there was a study conducted on a group of participants who were divided into placebo and phentermine groups. By the end of the trial, which lasted 14 weeks, it was found that the group that was administered a placebo noticed an average weight loss of about 2-3 kilograms, while the phentermine group noticed a weight reduction of about 7 kilograms.

So, both semaglutide and phentermine demonstrated the ability to help people lose weight via clinical trials.

Phentermine and Semaglutide – A Comparison


  • can be used in chronic weight management
  • showed the ability to help people lose weight via clinical trials
  • not available OTC (over the counter) – you need a prescription for them 
  • work by suppressing appetite 
  • should not be used when pregnant



  • Approved specifically for weight loss therapy
  • In the form of sustained-release capsules or tablets that dissolve in your mouth
  • Taken every day, in the morning
  • Meant for short-term use (approved for 12 weeks)
  • Affordable as a generic drug



  • Approved for type 2 diabetes (blood sugar control), weight loss is a secondary function

  • In the form of an injection

  • Taken weekly at the same time

  • Meant for long-term use

  • Can be expensive if not covered by insurance


The Bottom Line

Both Ozempic and phentermine have shown their capabilities to become prescription weight loss medications – however, at the moment, only one of them is approved by the FDA for that specific purpose, and that is phentermine.

Still, while Ozempic’s main purpose is to act as GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion, it has also been effective in helping people lose weight, as it can suppress appetite by making the person taking it feel full for longer.

Unfortunately, in many cases, Ozempic is not covered by insurance, which requires patients to buy it out-of-pocket, which can be expensive in the United States. At Ozempic Coupons, we aim to make this medication available at more affordable prices to people across the country, which is why we created a platform where we share the most up-to-date information and the best coupons for buying Ozempic online.

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